Tumor Necrosis Factor-α Mediates the Blood-Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells

• Autori principali: Tsuyoshi Nishioku (Autore), Junichi Matsumoto (Autore), Shinya Dohgu (Autore), Noriko Sumi (Autore), Kenji Miyao (Autore), Fuyuko Takata (Autore), Hideki Shuto (Autore), Atsushi Yamauchi (Autore), Yasufumi Kataoka (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2010-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The present study was designed to elucidate the involvement of tumor necrosis factor-α (TNF-α) release from activated microglia in the induction of blood-brain barrier (BBB) dysfunction in an in vitro co-culture system with mouse brain capillary endothelial cells (MBEC4) and microglia. Lipopolysacch...