Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs
Nonsense mutations or premature termination codons (PTCs) comprise ∼11% of all genetic lesions, which result in over 7,000 distinct genetic diseases. Due to their outsized impact on human health, considerable effort has been made to find therapies for nonsense-associated diseases. Suppressor tRNAs h...
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| Formato: | Livro |
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Elsevier,
2022-06-01T00:00:00Z.
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