Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect

• Principais autores: Erzsébet Pászti-Gere (Autor), Judit Pomothy (Autor), Ákos Jerzsele (Autor), Oliver Pilgram (Autor), Torsten Steinmetzer (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours. It was proven that treatment with MI-1900 and MI-1907 was tolerated up to 50 μM in HIEC-6. These inhi...