Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

• Main Authors: Svetlana A. Ivanova (Author), Valentina M. Alifirova (Author), Ivan V. Pozhidaev (Author), Maxim B. Freidin (Author), Irina A. Zhukova (Author), Diana Z. Osmanova (Author), Natalia G. Zhukova (Author), Yulia A. Mironova (Author), Vladimir V. Tiguntsev (Author), Olga Yu. Fedorenko (Author), Nikolay A. Bokhan (Author), Bob Wilffert (Author), Anton J.M. Loonen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigat...