Evaluation of Aminopolycarboxylate Chelators for Whole-Body Clearance of Free ²²⁵Ac: A Feasibility Study to Reduce Unexpected Radiation Exposure during Targeted Alpha Therapy

• Main Authors: Mitsuyoshi Yoshimoto (Author), Yukie Yoshii (Author), Hiroki Matsumoto (Author), Mitsuhiro Shinada (Author), Masashi Takahashi (Author), Chika Igarashi (Author), Fukiko Hihara (Author), Tomoko Tachibana (Author), Ayano Doi (Author), Tatsuya Higashi (Author), Hirofumi Fujii (Author), Kohshin Washiyama (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Actinium-225 (²²⁵Ac) is a promising radionuclide used in targeted alpha therapy (TAT). Although ²²⁵Ac labeling of bifunctional chelating ligands is effective, previous in vivo studies reported that free ²²⁵Ac can be released from t...