Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes
Purpose: Adefovir is an antiviral drug that exhibits high hydrophilic properties and negligible bioavailability (less than 12%). It is only applied in the form of the ester prodrug adefovir dipivoxil (ADV). The oral bioavailability of ADV is limited (32% to 45%) by its low permeability (Class 3) and...
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| Main Authors: | , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2018-05-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |