Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

• Main Authors: Masanori Horie (Author), Yukiko Yoshiura (Author), Hiroto Izumi (Author), Takako Oyabu (Author), Taisuke Tomonaga (Author), Takami Okada (Author), Byeong-Woo Lee (Author), Toshihiko Myojo (Author), Masaru Kubo (Author), Manabu Shimada (Author), Yasuo Morimoto (Author)
• Format: Book
• Published: MDPI AG, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative s...