Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma

• Main Authors: Lanxin Jiang (Author), Ying Zhou (Author), Shijie Tang (Author), Dan Yang (Author), Yixin Zhang (Author), Jiuge Zhang (Author), Fan Yang (Author), Tong Zhou (Author), Xiaoqiang Xia (Author), Qianming Chen (Author), Lu Jiang (Author), Yuchen Jiang (Author), Xiaodong Feng (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy. However, it is yet to be determined if targeting oncometabolite-associa...