Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization

• Asıl Yazarlar: Jinsong Su (Yazar), Fujing Yang (Yazar), Xuemei Kang (Yazar), Jia Liu (Yazar), Yiwen Tao (Yazar), Qingchun Diao (Yazar), Xianli Meng (Yazar), Deming Liu (Yazar), Yi Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Three chalcone derivatives, abelmanihotols A−C (1-3), and nine known compounds were isolated from A. manihot seeds, and their structures were determined using HRESIMS and NMR spectroscopic analysis. Compound 1 exhibited the most potent inhibitory effect (IC50 = 4.79 ± 0.72 μM) against lipopolysaccha...