Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization

• Main Authors: Jinsong Su (Author), Fujing Yang (Author), Xuemei Kang (Author), Jia Liu (Author), Yiwen Tao (Author), Qingchun Diao (Author), Xianli Meng (Author), Deming Liu (Author), Yi Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Three chalcone derivatives, abelmanihotols A−C (1-3), and nine known compounds were isolated from A. manihot seeds, and their structures were determined using HRESIMS and NMR spectroscopic analysis. Compound 1 exhibited the most potent inhibitory effect (IC50 = 4.79 ± 0.72 μM) against lipopolysaccha...