Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

IntroductionThymidylate synthase (TS) plays a crucial role in cellular growth, proliferation, DNA synthesis, and repair, thus gaining attention for targeted therapies in cancer. TS overexpression and the altered pharmacokinetics of anti-TS drugs are among the most prominent causes of cellular resist...

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Main Authors: Gaetano Marverti (Author), Maria Gaetana Moschella (Author), Alice Belardo (Author), Michele Lamesta (Author), Giada Mercanile (Author), Lorenzo Tagliazucchi (Author), Daniele Aiello (Author), Alberto Venturelli (Author), Davide Illuminati (Author), Remo Guerrini (Author), Lorena Losi (Author), Glauco Ponterini (Author), Maria Paola Costi (Author), Domenico D'Arca (Author)
Format: Book
Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
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