Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants

• Main Authors: Juliana P. Vago (Author), Natália Valdrighi (Author), Esmeralda N. Blaney-Davidson (Author), Daniel L. A. H. Hornikx (Author), Margot Neefjes (Author), María E. Barba-Sarasua (Author), Nathalie G. M. Thielen (Author), Martijn H. J. van den Bosch (Author), Peter M. van der Kraan (Author), Marije I. Koenders (Author), Flávio A. Amaral (Author), Fons A. J. van de Loo (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain. TAM receptors (Tyro3, Axl, and Mer) play an important role in regulating immune responses, clearing apoptotic c...