Epigallocatechin Gallate Induces the Demethylation of Actinin Alpha 4 to Inhibit Diabetic Nephropathy Renal Fibrosis via the NF-KB Signaling Pathway In Vitro

• Main Authors: Chunling He (Author), Dong Wang (Author), Ruoling Wang (Author), Yongli Huang (Author), Xin Huang (Author), ShuMin Shen (Author), Jun Lv (Author), Mingcai Wu (Author)
• Format: Book
• Published: SAGE Publishing, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Actinin alpha 4 ( ACTN4 ) is expressed in the kidney podocytes. ACTN4 gene methylation in patients with diabetic nephropathy (DN) remains high. Underlying mechanism of epigallocatechin-3-gallate (EGCG) inducing ACTN4 demethylation, and its inhibitory effect on DN renal fibrosis remains unclear. Meth...