Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

• Main Authors: Klingelhoeffer Christoph (Author), Kämmerer Ulrike (Author), Koospal Monika (Author), Mühling Bettina (Author), Schneider Manuela (Author), Kapp Michaela (Author), Kübler Alexander (Author), Germer Christoph-Thomas (Author), Otto Christoph (Author)
• Format: Book
• Published: BMC, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Ascorbic acid demonstrates a cytotoxic effect by generating hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative cell stress. A panel of eleven human cancer cell lines, glioblastoma and carcinoma, were exposed to...