Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

• Autori principali: Klingelhoeffer Christoph (Autore), Kämmerer Ulrike (Autore), Koospal Monika (Autore), Mühling Bettina (Autore), Schneider Manuela (Autore), Kapp Michaela (Autore), Kübler Alexander (Autore), Germer Christoph-Thomas (Autore), Otto Christoph (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2012-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Ascorbic acid demonstrates a cytotoxic effect by generating hydrogen peroxide, a reactive oxygen species (ROS) involved in oxidative cell stress. A panel of eleven human cancer cell lines, glioblastoma and carcinoma, were exposed to...