Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions. Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy. Reverse-phase LC-MS analysis of tetrabenazine aci...

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Main Authors: Laurent Ettouati (Author), Zoé Senta-Loys (Author), Sandrine Bourgeois (Author), Bernard Fenet (Author), Marc Le Borgne (Author), Hatem Fessi (Author)
Format: Book
Published: MDPI AG, 2019-01-01T00:00:00Z.
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