Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases

• Autori principali: Saira Afzal (Autore), Mariya al-Rashida (Autore), Abdul Hameed (Autore), Julie Pelletier (Autore), Jean Sévigny (Autore), Jamshed Iqbal (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Ectonucleoside triphosphate diphosphohydrolases (NTPDases) are ectoenzymes that play an important role in the hydrolysis of nucleoside triphosphate and diphosphate to nucleoside monophosphate. NTPDase1, -2, -3 and -8 are the membrane bound members of this enzyme family that are responsible for regul...