Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy

• Main Authors: Koshi Yamada (Author), Zhi qiang Huang (Author), Milan Raska (Author), Colin Reily (Author), Joshua C. Anderson (Author), Hitoshi Suzuki (Author), Krzysztof Kiryluk (Author), Ali G. Gharavi (Author), Bruce A. Julian (Author), Christopher D. Willey (Author), Jan Novak (Author)
• Format: Book
• Published: Karger Publishers, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: IgA nephropathy (IgAN) is thought to involve an autoimmune process wherein galactose-deficient IgA1 (Gd-IgA1), recognized as autoantigen by autoantibodies, forms pathogenic immune complexes. Mounting evidence has implicated abnormal activation of some protein-tyrosine kinases (PTKs) in I...