Stemness of Human Pluripotent Cells: Hypoxia-Like Response Induced by Low Nitric Oxide

• Main Authors: Estefanía Caballano-Infantes (Author), Irene Díaz (Author), Ana Belén Hitos (Author), Gladys Margot Cahuana (Author), Antonio Martínez-Ruiz (Author), Bárbara Soria-Juan (Author), Rosario Rodríguez-Griñolo (Author), Abdelkrim Hmadcha (Author), Franz Martín (Author), Bernat Soria (Author), Juan R. Tejedo (Author), Francisco Javier Bedoya (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The optimization of conditions to promote the stemness of pluripotent cells in vitro is instrumental for their use in advanced therapies. We show here that exposure of human iPSCs and human ESCs to low concentrations of the chemical NO donor DETA/NO leads to stabilization of hypoxia-inducible factor...