Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin

• Main Authors: Jin-Bo Yu (Author), Zhen-Xiong Zhao (Author), Ran Peng (Author), Li-Bin Pan (Author), Jie Fu (Author), Shu-Rong Ma (Author), Pei Han (Author), Lin Cong (Author), Zheng-Wei Zhang (Author), Li-Xin Sun (Author), Jian-Dong Jiang (Author), Yan Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paeoniflorin, the main component of Xiaoyao Wan, presents low oral bioavailability and unclear antidepressant mechanism. To elucidate the potential reasons for the low bioavailability of paeoniflorin and explore its antidepressant mechanism from the perspective of the gut microbiota, here, a chronic...