Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model

• Main Authors: Beatriz Llamusi (Author), Ariadna Bargiela (Author), Juan M. Fernandez-Costa (Author), Amparo Garcia-Lopez (Author), Raffaella Klima (Author), Fabian Feiguin (Author), Ruben Artero (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Myotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alter...