Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test

• Main Authors: Kaori Takahashi (Author), Daisuke Nishizawa (Author), Shinya Kasai (Author), Yoshihiko Koukita (Author), Ken-ichi Fukuda (Author), Tatsuya Ichinohe (Author), Kazutaka Ikeda (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducte...