Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules

• Egile Nagusiak: Chisato Terada (Egilea), Seiya Kawamoto (Egilea), Asako Yamayoshi (Egilea), Tsuyoshi Yamamoto (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Oligonucleotide therapeutics that can modulate gene expression have been gradually developed for clinical applications over several decades. However, rapid advances have been made in recent years. Artificial nucleic acid technology has overcome many challenges, such as (1) poor target affinity and s...