Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model

• Main Authors: Shinya Morita (Author), Kazunobu Shinoda (Author), Tadashi Yoshida (Author), Masayuki Shimoda (Author), Yoshihiko Kanno (Author), Ryuichi Mizuno (Author), Hidaka Kono (Author), Hiroshi Asanuma (Author), Ken Nakagawa (Author), Kazuo Umezawa (Author), Mototsugu Oya (Author)
• Format: Book
• Published: BMC, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cyclosporine A (CsA) is an essential immunosuppressant in organ transplantation. However, its chronic nephrotoxicity is an obstacle to long allograft survival that has not been overcome. Nuclear factor-κB (NF-κB) is activated in the renal tissue in CsA nephropathy. In this study,...