A Second Generation Mn-Porphyrin Dimer with a Twisted Linker as a Potential Blood Pool Agent for MRI: Tuning the Geometry and Binding with HSA

• Главные авторы: Hanlin Liu (Автор), Weiran Cheng (Автор), Shili Dong (Автор), David Feng Xu (Автор), Keith Tang (Автор), Xiao-an Zhang (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2020-09-01T00:00:00Z.
• Предметы: article
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Blood-pool agents (BPAs) are MRI contrast agents (CAs) characterized by their long circulation in the vascular system to provide an extended time window for high-resolution MR angiography (MRA). Prolonged vascular retention, however, impedes the excretion of BPAs. Therefore, chemical strategy to reg...