A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model

• 主要な著者: Chana Yagil (著者), Ronen Varadi-Levi (著者), Yoram Yagil (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2018-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The mechanisms underlying diabetes remain unresolved. The Cohen diabetic rat represents a model of diet-induced diabetes, in which the disease is induced after exposure to a diabetogenic diet (DD) in the diabetes-sensitive (CDs/y) but not in the -resistant (CDr/y) strain. Diet imposes a metabolic st...