Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug

• Main Authors: Danielle de Brito e Cunha (Author), Ana Beatriz Teixeira Frederico (Author), Tamiris Azamor (Author), Juliana Gil Melgaço (Author), Patricia Cristina da Costa Neves (Author), Ana Paula Dinis Ano Bom (Author), Tatiana Martins Tilli (Author), Sotiris Missailidis (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic degradation of siRNAs by serum endonucleases and RN...