A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

• Main Authors: Martha Sahylí Ortega Pijeira (Author), Sofia Nascimento dos Santos (Author), Yasniel Babi Araujo (Author), André Luis Lapolli (Author), Marcio Nardelli Wandermuren (Author), Zalua Rodríguez Riera (Author), Ivone Carvalho (Author), Philip H. Elsinga (Author), Emerson Soares Bernardes (Author)
• Format: Book
• Published: SpringerOpen, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background 2-[18F]Fluoroethyltosylate ([18F]FEtOTs) is a well-known 18F-fluoroalkylating agent widely used to synthesize radiotracers for positron emission tomography. The widespread use of [18F]FEtOTs is due in part to its low volatility when compared to other halide and sulfonate building...