Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

• Main Authors: Mengjie Jiang (Author), Jinjin Fan (Author), Xinli Qu (Author), Songhui Li (Author), Susan K. Nilsson (Author), Yu Bo Yang Sun (Author), Yaping Chen (Author), Di Yu (Author), Dan Liu (Author), Bi-Cheng Liu (Author), Mingliang Tang (Author), Wei Chen (Author), Yi Ren (Author), David J. Nikolic-Paterson (Author), Xiaoyun Jiang (Author), Jinhua Li (Author), Xueqing Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury leading to chronic kidney disease through tubulointerstitial fibrosis is a major challenge in nephropathy. Several signaling pathways promote interstitial fibrosis; however, effective suppression of fibrosis may require blockade of more than one pathway. This study investigated w...