Rational selection of building blocks for the assembly of bispecific antibodies

• Main Authors: Danyang Gong (Author), Timothy P. Riley (Author), Krzysztof P. Bzymek (Author), Ana R. Correia (Author), Danqing Li (Author), Christopher Spahr (Author), John H. Robinson (Author), Ryan B. Case (Author), Zhulun Wang (Author), Fernando Garces (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bispecific antibodies, engineered to recognize two targets simultaneously, demonstrate exceptional clinical potential for the therapeutic intervention of complex diseases. However, these molecules are often composed of multiple polypeptide chains of differing sequences. To meet industrial scale prod...