Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System

• Main Authors: Rishab Shyam (Author), Yong Ren (Author), Jason Lee (Author), Kerstin E Braunstein (Author), Hai-Quan Mao (Author), Philip C Wong (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a progressive neurodegenerative disease currently lacking effective treatment. Efficient delivery of siRNA via nanoparticles may emerge as a viable therapeutic approach to treat AD and other central nervous system disorders. We report here the use of a linear polyeth...