DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

• Main Authors: Jiaxuan Liu (Author), Wei Zhao (Author), Erin B. Ware (Author), Stephen T. Turner (Author), Thomas H. Mosley (Author), Jennifer A. Smith (Author)
• פורמט: ספר
• יצא לאור: BMC, 2018-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Background Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expr...