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DNA methylation in the APOE genomic region is associated with cognitive function in African Americans

Abstract Background Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expr...

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Main Authors: Jiaxuan Liu (Author), Wei Zhao (Author), Erin B. Ware (Author), Stephen T. Turner (Author), Thomas H. Mosley (Author), Jennifer A. Smith (Author)
Format: Book
Published: BMC, 2018-05-01T00:00:00Z.
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