Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma

• Main Authors: Monica Benvenuto (Author), Rosanna Mattera (Author), Joshua Ismaele Sticca (Author), Piero Rossi (Author), Chiara Cipriani (Author), Maria Gabriella Giganti (Author), Antonio Volpi (Author), Andrea Modesti (Author), Laura Masuelli (Author), Roberto Bei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting mult...