Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8.

• Main Authors: Tirza Gabrielle Ramos de Mesquita (Author), José do Espírito Santo Junior (Author), Thais Carneiro de Lacerda (Author), Krys Layane Guimarães Duarte Queiroz (Author), Cláudio Marcello da Silveira Júnior (Author), José Pereira de Moura Neto (Author), Lissianne Augusta Matos Gomes (Author), Mara Lúcia Gomes de Souza (Author), Marcus Vinitius de Farias Guerra (Author), Rajendranath Ramasawmy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania are intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regulatory role in numerous biological processes includi...