Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

• Main Authors: Ryan D.R. Brown (Author), Christopher D. Green (Author), Cynthia Weigel (Author), Bin Ni (Author), Francesco S. Celi (Author), Richard L. Proia (Author), Sarah Spiegel (Author)
• 格式: 圖書
• 出版: Elsevier, 2024-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Objective: The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) accumulate with overnutrition and have been implicated in non-alcoholic steatohepatitis (NASH) development. ORMDL3, a negative regulator of the rate-limiting step in ceramide biosynthesis, has been identifie...