Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

Objective: The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) accumulate with overnutrition and have been implicated in non-alcoholic steatohepatitis (NASH) development. ORMDL3, a negative regulator of the rate-limiting step in ceramide biosynthesis, has been identifie...

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Main Authors: Ryan D.R. Brown (Author), Christopher D. Green (Author), Cynthia Weigel (Author), Bin Ni (Author), Francesco S. Celi (Author), Richard L. Proia (Author), Sarah Spiegel (Author)
Format: Book
Published: Elsevier, 2024-01-01T00:00:00Z.
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3rd Floor Main Library

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