Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information led us to propose hybrids of TUB015 and nocod...

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Main Authors: Marta Gargantilla (Author), Leentje Persoons (Author), Tereza Kauerová (Author), Natalia del Río (Author), Dirk Daelemans (Author), Eva-María Priego (Author), Peter Kollar (Author), María-Jesús (Author)
Format: Book
Published: MDPI AG, 2022-07-01T00:00:00Z.
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