Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)

• Үндсэн зохиолчид: Marta Gargantilla (Зохиогч), Leentje Persoons (Зохиогч), Tereza Kauerová (Зохиогч), Natalia del Río (Зохиогч), Dirk Daelemans (Зохиогч), Eva-María Priego (Зохиогч), Peter Kollar (Зохиогч), María-Jesús (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2022-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information led us to propose hybrids of TUB015 and nocod...