Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8a (IC50 = 3.93 μmol/L) and fu...
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Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Book |
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Elsevier,
2019-07-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |