Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control

• Main Authors: Wagner S. Dantas (Author), Elizabeth R.M. Zunica (Author), Elizabeth C. Heintz (Author), Bolormaa Vandanmagsar (Author), Z. Elizabeth Floyd (Author), Yongmei Yu (Author), Hisashi Fujioka (Author), Charles L. Hoppel (Author), Kathryn P. Belmont (Author), Christopher L. Axelrod (Author), John P. Kirwan (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously...