Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650

• Main Authors: Simone Ladel (Author), Patrick Schlossbauer (Author), Johannes Flamm (Author), Harald Luksch (Author), Boris Mizaikoff (Author), Katharina Schindowski (Author)
• Formato: Libro
• Publicado: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in vitro models are required. Here, porcine olfactory (OEPC) and respiratory (REPC) primary cells were characteris...