Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial)

• Main Authors: Serife Kurul (Author), H. Rob Taal (Author), Robert B. Flint (Author), Jan Mazela (Author), Irwin K. M. Reiss (Author), Karel Allegaert (Author), Sinno H. P. Simons (Author)
• Format: Book
• Published: BMC, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Late onset sepsis is a leading cause of death and morbidity in preterm infants. Despite optimal antibiotic treatment, sepsis related mortality and morbidity is still high. Pentoxifylline (PTX) is a methylxanthine with promising immunomodulatory properties, which can be used as an...