Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

• Main Authors: Soraia Silva (Author), Joana Bicker (Author), Amílcar Falcão (Author), Ana Fortuna (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics has highlighted the importance of drug dosing-time. Circadian oscillations alter drug absorption, distribution, metabolism, and excretion (ADME) as well as intracellular signaling systems, target molecules (e.g.,...