Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

• Main Authors: Puneet Tyagi (Author), Chandresh Patel (Author), Kimberly Gibson (Author), Fiona MacDougall (Author), Sergei Y. Pechenov (Author), Sarah Will (Author), Jefferson Revell (Author), Yue Huang (Author), Anton I. Rosenbaum (Author), Kemal Balic (Author), Umar Maharoof (Author), Joseph Grimsby (Author), J. Anand Subramony (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic variability. Our earlier work focused on the discover...