Serial five-membered lactone ring ions in the treatment of Alzheimer's diseases-comprehensive profiling of arctigenin metabolites and network analysis

• Main Authors: Yanan Li (Author), Xianming Lan (Author), Shaoping Wang (Author), Yifang Cui (Author), Shuyi Song (Author), Hongyan Zhou (Author), Qiyan Li (Author), Long Dai (Author), Jiayu Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arctigenin is a phenylpropanoid dibenzylbutyro lactone lignan compound with multiple biological functions. Previous studies have shown that arctigenin have neuroprotective effects in Alzheimer's disease (AD) models both in vivo and in vitro; however, its metabolism in vivo has not been studied....