Serial five-membered lactone ring ions in the treatment of Alzheimer's diseases-comprehensive profiling of arctigenin metabolites and network analysis

• Autores principales: Yanan Li (Autor), Xianming Lan (Autor), Shaoping Wang (Autor), Yifang Cui (Autor), Shuyi Song (Autor), Hongyan Zhou (Autor), Qiyan Li (Autor), Long Dai (Autor), Jiayu Zhang (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Arctigenin is a phenylpropanoid dibenzylbutyro lactone lignan compound with multiple biological functions. Previous studies have shown that arctigenin have neuroprotective effects in Alzheimer's disease (AD) models both in vivo and in vitro; however, its metabolism in vivo has not been studied....