Replacing the phthalimide core in thalidomide with benzotriazole

• Hauptverfasser: Mikhail Krasavin (Verfasst von), Andrey Bubyrev (Verfasst von), Alexander Kazantsev (Verfasst von), Christopher Heim (Verfasst von), Samuel Maiwald (Verfasst von), Daniil Zhukovsky (Verfasst von), Dmitry Dar'in (Verfasst von), Marcus D. Hartmann (Verfasst von), Alexander Bunev (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide glutarimide core) bind to Cereblon, the substrate rec...