Replacing the phthalimide core in thalidomide with benzotriazole

• Main Authors: Mikhail Krasavin (Author), Andrey Bubyrev (Author), Alexander Kazantsev (Author), Christopher Heim (Author), Samuel Maiwald (Author), Daniil Zhukovsky (Author), Dmitry Dar'in (Author), Marcus D. Hartmann (Author), Alexander Bunev (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide glutarimide core) bind to Cereblon, the substrate rec...