Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans

• Main Authors: J. R. Bosley (Author), Elias Björnson (Author), Cheng Zhang (Author), Hasan Turkez (Author), Jens Nielsen (Author), Mathias Uhlen (Author), Jan Borén (Author), Adil Mardinoglu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To determine how to set optimal oral L-serine (serine) dose levels for a clinical trial, existing literature was surveyed. Data sufficient to set the dose was inadequate, and so an (n = 10) phase I-A calibration trial was performed, administering serine with and without other oral agents. We analyze...