Cholesterol Oxidase Binds TLR2 and Modulates Functional Responses of Human Macrophages

• Egile Nagusiak: Katarzyna Bednarska (Egilea), Michal Kielbik (Egilea), Zofia Sulowska (Egilea), Jaroslaw Dziadek (Egilea), Magdalena Klink (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2014-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cholesterol oxidase (ChoD) is considered to be an important virulence factor for Mycobacterium tuberculosis (Mtb), but its influence on macrophage activity is unknown. Here we used Nocardia erythropolis ChoD, which is very similar to the Mtb enzyme (70% identity at the amino-acid level), to evaluate...