Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome
Objective: Extreme obesity is a core phenotypic feature of Prader-Willi syndrome (PWS). Among numerous metabolic regulators, the endocannabinoid (eCB) system is critically involved in controlling feeding, body weight, and energy metabolism, and a globally acting cannabinoid-1 receptor (CB1R) blockad...
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Elsevier,
2016-12-01T00:00:00Z.
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