Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

• Main Authors: Mario A. Moscarello (Author), Helena Lei (Author), Fabrizio G. Mastronardi (Author), Shawn Winer (Author), Hubert Tsui (Author), Zhen Li (Author), Cameron Ackerley (Author), Li Zhang (Author), Reinout Raijmakers (Author), D. Denise Wood (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deimin...