Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes

• Main Authors: Xuemei Cao (Author), Min Mao (Author), Junlin Diao (Author), Yi Hou (Author), Hong Su (Author), Yongjun Gan (Author), Jibin Li (Author), Xiaoyong Tong (Author), Chaodong Wu (Author), Zhong Zuo (Author), Xiaoqiu Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical controversy of rosiglitazone as a hypoglycemic agent is potentially associated with heart failure, mainly due to its potent activation of peroxisome proliferator-activated receptor γ (PPARγ). PPARγ partial agonists showed superior pharmacological profiles to rosiglitazone. This study co...