Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal <i>SHP-1</i> and <i>SOCS-3</i> Hypermethylation: In Vitro and In Silico Evaluation

• Main Authors: Futoon Abedrabbu Al-Rawashde (Author), Muhammad Farid Johan (Author), Wan Rohani Wan Taib (Author), Imilia Ismail (Author), Syed Ahmad Tajudin Tuan Johari (Author), Belal Almajali (Author), Abdullah Saleh Al-wajeeh (Author), Mansoureh Nazari Vishkaei (Author), Hamid Ali Nagi Al-Jamal (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic silencing of tumor suppressor genes (TSGs) plays an essential role in cancer pathogenesis, including acute myeloid leukemia (AML). All of <i>SHP-1</i>, <i>SOCS-1</i>, and <i>SOCS-3</i> are TSGs that negatively regulate JAK/STAT signaling. Enhanced re-ex...